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An Efficient and Facile Multicomponent Reaction for the Synthesis of 5′,6′‐dihydro‐6′‐hydroxy‐6′‐(trifluoromethyl)‐1′ H ‐spiro[indoline‐3,4′‐pyrimidine]‐2,2′(3′ H )‐dione Derivatives under Solvent‐Free Conditions
Author(s) -
Xu Hui,
Yan Lirong,
Qin Yaqi,
Xu Zhongyun,
Ling Zhi,
Rong Liangce
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2851
Subject(s) - chemistry , trifluoromethyl , indoline , urea , pyrimidine , solvent , organic chemistry , reaction conditions , catalysis , stereochemistry , alkyl
The reactions of isatins, urea, and different diketones under solvent‐free conditions have been developed for the preparation of novel spiroheterocycles. It was found that these reactions could be given higher yields and required shorter time compared with commonly used volatile organic solvent conditions. In this synthesis, the important group trifluoromethyl was introduced into the structure of the products. The pure products could be obtained only through removing TsOH, isatins, and urea from hot water. At same time, diketone was eliminated through a small amount of EtOH. Other advantages of this method are simple setup, mild conditions, and minimal environment impact.