Premium
One‐pot Synthesis of 3‐phenyl‐4‐pyrazolylmethylene‐isoxazol‐(5 H )‐ones Catalyzed by Sodium Benzoate in Aqueous Media under the Influence of Ultrasound Waves: A Green Chemistry Approach
Author(s) -
Konkala Veera Swamy,
Dubey Pramod Kumar
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2848
Subject(s) - chemistry , knoevenagel condensation , catalysis , hydroxylamine hydrochloride , pyrazole , aqueous solution , organic chemistry , hydrochloride , aqueous medium , condensation reaction , sodium benzoate , aldehyde , food science
A series of 4‐pyrazolylmethylene‐3‐phenylisoxazol‐5(4 H )‐ones have been prepared from Knoevenagel condensation of pyrazole‐4‐carbaxaldehyde with isoxazolone precursors or via one‐pot three‐component cyclocondensation of pyrazole‐4‐carbaxaldehyde with β‐ketoesters and hydroxylamine hydrochloride in the presence of sodium benzoate in water under the influence of ultrasonic waves. The merits of this method are efficient, clean, green, easy work‐up, high yields, and shorter reaction time, and the catalyst could be recycled easily without affecting the catalytic activity.