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Design and Synthesis Pairing Between Xanthene and Tetrazole in Pentacyclic System Using Tetrachlorosilane with Aurora Kinase Inhibitor Validation
Author(s) -
Khatab Tamer K.,
Mubarak Ahmed Y.,
Soliman Hanan A.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2846
Subject(s) - chemistry , xanthene , tetrazole , sodium azide , dimedone , acetonitrile , molecule , docking (animal) , solvent , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis , medicine , nursing
A competent new one‐pot synthesis for tetrahydrobenzo[f]chromeno[3,2‐c]tetrazolo[1,5‐a]azepines through the catalytic synthesis of related xanthenes. β‐naphthol, dimedone, aromatic aldehydes were stirred under solvent free condition in the presence of tetrachlorosilane (TCS), then azidochlorosilane (which prepared in situ from sodium azide and TCS in acetonitrile as solvent) was added and the reaction was stirred at 50‐60 oC. A molecular docking of the synthesized compounds was carried out in order to investigate their binding pattern with the prospective target Aurora kinase all the synthesized molecules gave strong interaction with protein pocket residues and low energy score (−6.99 to −6.52 kcal/mol and rmsd < 1.5) compared with AKI‐001 reference molecule (−5.87 kcal/mol and rmsd = 0.90). (PDB‐ID: 3COH)