Three‐Component Synthesis of Spiro[indoline‐3,4′‐pyrazolo[3,4‐ b ]pyridines] under Microwave Irradiation | Zendy

Gao Xia | Zendy; Yang Zheng | Zendy; Hao WenJuan | Zendy; Jiang Bo | Zendy; Tu ShuJiang | Zendy

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Three‐Component Synthesis of Spiro[indoline‐3,4′‐pyrazolo[3,4‐ b ]pyridines] under Microwave Irradiation

Author(s) -

Gao Xia,

Yang Zheng,

Hao WenJuan,

Jiang Bo,

Tu ShuJiang

Publication year - 2017

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2840

Subject(s) - indoline , chemistry , microwave irradiation , domino , microwave , combinatorial chemistry , cascade reaction , isatin , component (thermodynamics) , multi component reaction , drug discovery , organic chemistry , catalysis , biochemistry , quantum mechanics , thermodynamics , physics

A domino three‐component strategy with high efficiency for the synthesis of spiro[indoline‐3,4′‐pyrazolo[3,4‐ b ]pyridines] from easily available isatins, pyrazol‐5‐amines and β ‐ketonitriles under microwave heating. During reaction process, HOAc plays dual roles as reaction media as well as a Brønsted acid‐promoter. Flexible structural modification, broad functional group compatibility and mild reaction conditions make this strategy a useful and attractive process of library generation for drug discovery.

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