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Three‐Component Synthesis of Spiro[indoline‐3,4′‐pyrazolo[3,4‐ b ]pyridines] under Microwave Irradiation
Author(s) -
Gao Xia,
Yang Zheng,
Hao WenJuan,
Jiang Bo,
Tu ShuJiang
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2840
Subject(s) - indoline , chemistry , microwave irradiation , domino , microwave , combinatorial chemistry , cascade reaction , isatin , component (thermodynamics) , multi component reaction , drug discovery , organic chemistry , catalysis , biochemistry , quantum mechanics , thermodynamics , physics
A domino three‐component strategy with high efficiency for the synthesis of spiro[indoline‐3,4′‐pyrazolo[3,4‐ b ]pyridines] from easily available isatins, pyrazol‐5‐amines and β ‐ketonitriles under microwave heating. During reaction process, HOAc plays dual roles as reaction media as well as a Brønsted acid‐promoter. Flexible structural modification, broad functional group compatibility and mild reaction conditions make this strategy a useful and attractive process of library generation for drug discovery.