[Bis‐(trifluoroacetoxy)iodo]benzene‐Mediated Oxidative Direct Amination C–N Bond Formation: Synthesis of 1 H ‐Indazoles | Zendy

Zhang Zhiguo | Zendy; Huang Yuanyuan | Zendy; Huang Guoqing | Zendy; Zhang Guisheng | Zendy; Liu Qingfeng | Zendy

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[Bis‐(trifluoroacetoxy)iodo]benzene‐Mediated Oxidative Direct Amination C–N Bond Formation: Synthesis of 1 H ‐Indazoles

Author(s) -

Zhang Zhiguo,

Huang Yuanyuan,

Huang Guoqing,

Zhang Guisheng,

Liu Qingfeng

Publication year - 2017

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2839

Subject(s) - chemistry , benzene , oxidative phosphorylation , amination , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , biochemistry

An efficient [bis‐(trifluoroacetoxy)iodo]benzene (PIFA)‐mediated oxidative C‐N bond formation is developed for the synthesis of 1 H ‐indazoles from readily available arylhydrazones. The reaction tolerates a wide range of functional groups and has broad scope of substrates. Moreover, this method is a relative green and reliable method for rapid preparation of substituted 1 H ‐indazoles under mild conditions.

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