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[Bis‐(trifluoroacetoxy)iodo]benzene‐Mediated Oxidative Direct Amination C–N Bond Formation: Synthesis of 1 H ‐Indazoles
Author(s) -
Zhang Zhiguo,
Huang Yuanyuan,
Huang Guoqing,
Zhang Guisheng,
Liu Qingfeng
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2839
Subject(s) - chemistry , benzene , oxidative phosphorylation , amination , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , biochemistry
An efficient [bis‐(trifluoroacetoxy)iodo]benzene (PIFA)‐mediated oxidative C‐N bond formation is developed for the synthesis of 1 H ‐indazoles from readily available arylhydrazones. The reaction tolerates a wide range of functional groups and has broad scope of substrates. Moreover, this method is a relative green and reliable method for rapid preparation of substituted 1 H ‐indazoles under mild conditions.