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One‐pot Three Component Synthesis of ω‐( oxathiolan ‐2‐ thion ‐5‐yl)‐α‐ oxazolidin ‐2‐ones
Author(s) -
Ghrab Saad,
Aroua Lotfi,
Beji Mohamed
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2834
Subject(s) - chemistry , isocyanate , carbon disulfide , bromide , organic chemistry , disulfide bond , lithium bromide , combinatorial chemistry , catalysis , biochemistry , polyurethane , physics , heat exchanger , thermodynamics
We report a practical and one‐pot synthesis of novel series of ω‐(oxathiolan‐2‐thione‐5‐yl)‐α‐ oxazolidin‐2‐ones ( 3a‐h ). The obtained compounds have been designed, synthesized via reaction of oligoethylene glycols diglycidyl ethers, isocyanate and carbon disulfide in the presence of catalytic amount of lithium bromide. A variety of important oxazolidinone derivatives can be obtained from simple starting materials in good yields and the biological activity of these new products will be investigated in complementary study.