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New Trends of Acetonitrile Moiety in Heterocyclic Synthesis: Synthesis of Some Novel Pyrazole Derivatives as Antibacterial and Antifungal Agents
Author(s) -
ElMekawy Rasha E.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2828
Subject(s) - chemistry , pyrazole , aspergillus fumigatus , pseudomonas fluorescens , moiety , fusarium oxysporum , antimicrobial , pseudomonas , bacteria , stereochemistry , combinatorial chemistry , microbiology and biotechnology , organic chemistry , genetics , botany , biology
This manuscript describes the synthesis of novel series of pyrazole derivatives 4a–d , 6a–d , and 10a–d , and they were examined for their antimicrobial activity against Staphylococcus aureus and Streptococcus pyogenes as examples of Gram positive bacteria and Pseudomonas fluorescens and Pseudomonas phaseolicola as examples of Gram negative bacteria and also Fusarium oxysporum and Aspergillus fumigatus as fungal strains. Different methodologies were employed to construct this scaffold. Among these compounds, a series of pyrazole derivatives 4a–d and 6a–d exhibited a great degree of potency against some microbial strains including multidrug resistant strains. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV– Vis , IR, 13 C NMR, 1 H NMR spectroscopy, and mass spectral data.