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Antibacterial and Antifungal Activities of 2‐(substituted ether)‐5‐(1‐phenyl‐5‐(trifluoromethyl)‐1 H ‐pyrazol‐4‐yl)‐1,3,4‐oxadiazole Derivatives
Author(s) -
Zhang TengTeng,
Wang PeiYi,
Zhou Jian,
Shao WuBin,
Fang HeShu,
Zhou Xiang,
Wu ZhiBing
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2820
Subject(s) - rhizoctonia solani , chemistry , trifluoromethyl , fusarium oxysporum , moiety , xanthomonas oryzae , oxadiazole , antimicrobial , antibacterial activity , pyrazole , bioassay , triazine , fusarium , stereochemistry , ec50 , amide , organic chemistry , bacteria , biochemistry , in vitro , botany , alkyl , genetics , gene , biology
By replacing the amide bond into 1,3,4‐oxadiazole moiety, a series of 1‐phenyl‐5‐(trifluoromethyl)‐1H‐pyrazole derivatives bearing 1,3,4‐oxadiazole were synthesized and evaluated their antibacterial and antifungal activity. The bioassay results revealed that compounds 7a and 7b showed the strongest antibacterial activity toward pathogen Xanthomonas oryzae pv. oryzae with the EC50 values of 15.0 and 6.4 µg/mL, respectively; compound 6a exhibited comprehensive antifungal activity toward six kinds of fungi; compound 6f could selectively inhibit the growth of Sclertinia sclerotiorum and Rhizoctonia solani with the inhibition rates of 82.5 and 80.3% at the concentrate of 100 µg/mL, respectively; compound 7b exerted good antifungal activity toward Fusarium oxysporum, Cytospora mandshurica, and Rhizoctonia solani with the inhibition rates of 70.8, 69.5, and 71.5%, respectively. The results suggested that this kind of compounds could be further studied as promising antimicrobial agents.