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C 5 ‐Alkyl‐1,3,4‐Oxadiazol‐2‐ones Undergo Dealkylation upon Nitrogen Insertion to Form 2 H ‐1,2,4‐Triazol‐3‐ones: Synthesis of 1,2,4‐Triazol‐3‐one Hybrids with Triazolothiadiazoles and Triazolothiadiazines
Author(s) -
Kattimani Pramod P.,
Kamble Ravindra R.,
Dorababu Atukuri,
Hunnur Raveendra K.,
Kamble Atulkumar A.,
Devarajegowda H.C.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2813
Subject(s) - chemistry , formamide , alkyl , alkylation , aryl , thiadiazoles , medicinal chemistry , nitrogen , stereochemistry , organic chemistry , catalysis
The present study emphasizes on the dealklylation of 3‐aryl‐5‐alkyl‐2‐oxo‐Δ 4 ‐1,3,4‐oxadiazoles when reacted with formamide resulting in the formation of 2‐aryl‐2 H ‐1,2,4‐triazol‐3(4 H )‐ones as major product. Subsequent reactions of 2‐aryl‐2 H ‐1,2,4‐triazol‐3(4 H )‐one gave triazolo[3,4‐ b ][1,3,4]thiadiazoles and triazolo[3,4‐ b ][1,3,4]thiadiazines derivatives incorporated with 1,2,4‐triazol‐3‐one.