C 5 ‐Alkyl‐1,3,4‐Oxadiazol‐2‐ones Undergo Dealkylation upon Nitrogen Insertion to Form 2 H ‐1,2,4‐Triazol‐3‐ones: Synthesis of 1,2,4‐Triazol‐3‐one Hybrids with Triazolothiadiazoles and Triazolothiadiazines | Zendy

Kattimani Pramod P. | Zendy; Kamble Ravindra R. | Zendy; Dorababu Atukuri | Zendy; Hunnur Raveendra K. | Zendy; Kamble Atulkumar A. | Zendy; Devarajegowda H.C. | Zendy

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C 5 ‐Alkyl‐1,3,4‐Oxadiazol‐2‐ones Undergo Dealkylation upon Nitrogen Insertion to Form 2 H ‐1,2,4‐Triazol‐3‐ones: Synthesis of 1,2,4‐Triazol‐3‐one Hybrids with Triazolothiadiazoles and Triazolothiadiazines

Author(s) -

Kattimani Pramod P.,

Kamble Ravindra R.,

Dorababu Atukuri,

Hunnur Raveendra K.,

Kamble Atulkumar A.,

Devarajegowda H.C.

Publication year - 2017

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2813

Subject(s) - chemistry , formamide , alkyl , alkylation , aryl , thiadiazoles , medicinal chemistry , nitrogen , stereochemistry , organic chemistry , catalysis

The present study emphasizes on the dealklylation of 3‐aryl‐5‐alkyl‐2‐oxo‐Δ 4 ‐1,3,4‐oxadiazoles when reacted with formamide resulting in the formation of 2‐aryl‐2 H ‐1,2,4‐triazol‐3(4 H )‐ones as major product. Subsequent reactions of 2‐aryl‐2 H ‐1,2,4‐triazol‐3(4 H )‐one gave triazolo[3,4‐ b ][1,3,4]thiadiazoles and triazolo[3,4‐ b ][1,3,4]thiadiazines derivatives incorporated with 1,2,4‐triazol‐3‐one.

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