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An efficient synthesis of pyrido[2,3‐ d ]pyrimidine derivatives in ionic liquid
Author(s) -
Shi DaQing,
Zhou Yao,
Liu Hai
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.281
Subject(s) - chemistry , pyrimidine , ionic liquid , catalysis , combinatorial chemistry , reaction conditions , ionic bonding , organic chemistry , stereochemistry , ion
A series of 5,7‐diarylpyrido[2,3‐ d ]pyrimidine‐2,4(1 H ,3 H )‐diones was synthesized via the reaction of 6‐aminopyrimidine‐2,4‐dione and α,β‐unsaturated ketones in ionic liquid without using any catalyst. This protocol has the advantages of easier work‐up, milder reaction conditions, high yields, and environmentally benign procedure over traditional methods. J. Heterocyclic Chem., 2010.