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One‐pot Three‐component Synthesis of Furan‐based Heterocycles from Benzyl Halides
Author(s) -
Beerappa Mallappa,
Shivashankar Kalegowda
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2806
Subject(s) - chemistry , furan , halide , isocyanide , yield (engineering) , cycloaddition , combinatorial chemistry , organic chemistry , component (thermodynamics) , one pot synthesis , catalysis , physics , thermodynamics , materials science , metallurgy
An efficient and a novel approach for the synthesis of furochromene and furopyran scaffolds are described. Benzyl halides undergo oxidation in Kornblum conditions to give the corresponding aldehydes, which in turn undergo [4 + 1] cycloaddition reaction with isocyanide to afford the corresponding furan derivatives. The significant attraction of this protocol is simple procedure, mild reaction condition, and good yield.