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Synthesis and Antimicrobial Activity of Unsymmetrical Dendrimers With Indazole, Salicylates and Anthranilates as Surface Units
Author(s) -
Jayanthi Mani,
Rajakumar Perumal
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2793
Subject(s) - chemistry , indazole , dendrimer , antimicrobial , combinatorial chemistry , organic chemistry
Unsymmetrical dendrimers with indazole and methyl/ ethyl/ isopropyl salicylates as surface units and 4‐(bromomethyl)phenol as core unit were synthesized in good yields by O‐alkylation. Similarly unsymmetrical dendrimers with indazole and methyl/ ethyl/ isopropyl anthranilates as surface units and 4‐hydroxybenzoic acid as core unit were synthesized in good yields by amide coupling reaction. The antimicrobial activities of the newly synthesized dendrimers were evaluated against four human pathogenic bacteria viz., E. coli, S. aureus, P. aeruginosa and B. subtilis under in vitro conditions by “cup plate method”.