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Synthesis and Anti‐influenza Virus Activity of Novel bis(4 H ‐chromene‐3‐carbonitrile) Derivatives
Author(s) -
Abdella Amna M.,
Moatasim Yassmin,
Ali Mohamed A.,
Elwahy Ahmed H. M.,
Abdelhamid Ismail A.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2776
Subject(s) - chemistry , malononitrile , dimedone , piperidine , catalysis , indene , organic chemistry , medicinal chemistry , combinatorial chemistry
An efficient and convenient method for the synthesis of bis(4 H ‐chromene‐3‐carbonitrile) derivatives by one‐pot, multicomponent reaction of bis‐aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine is reported. Bis(2‐benzylidene‐1 H ‐indene)‐1,3‐(2 H )‐dione derivatives were obtained as the main products as a result of reaction of the bis(arylidenemalononitriles) with indandione. The anti‐influenza H5N1 virus activities of the newly prepared bis‐chromene derivatives are also investigated.