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Novel and one‐pot Synthesis of Tetrahydropyrrolo[1,2‐ a ]‐2‐Methylbenzothiazole‐3‐Spiro‐1 ′ ‐Cyclohexa‐2 ′ ,5 ′ ‐Dien‐4 ′ ‐one‐4,5‐Dicarboxylate Derivatives via a Three Component Reaction
Author(s) -
Milani F. J.,
Nassiri M.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2774
Subject(s) - chemistry , dimethyl acetylenedicarboxylate , benzothiazole , phenol , condensation , acetylenedicarboxylate , catalysis , medicinal chemistry , organic chemistry , cycloaddition , physics , thermodynamics
The three component condensation reactions involving 2‐methylbenzothiazole or 2,5‐dimethylbenzothiazole, dialkyl acetylenedicarboxylate, and 2,6‐dimethyl phenol or 2,6‐di‐tert‐butylphenol constitute a novel and one‐pot synthesis of tetrahydropyrrolo[1,2‐ a ]‐2‐methylbenzothiazoles‐3‐spiro‐1 ′ ‐cyclohexa‐2 ′ ,5 ′ ‐dien‐4 ′ ‐one‐4,5‐dicarboxylate derivatives in good yields. The reactions proceeded at room temperature without using any catalyst. This method is very useful to functionalize benzothiazole derivatives in a one‐pot operation.