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Synthesis and fungicidal activity of 2‐substituted‐3‐(4‐fluorophenyl)‐benzofuro [3,2‐d] pyrimidin‐4(3H)‐ones
Author(s) -
Hu YangGen,
Xu Jing,
Gao HaiTao,
Ma Zuan
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.277
Subject(s) - chemistry , carbodiimide , yield (engineering) , isocyanate , nucleophile , medicinal chemistry , bioassay , organic chemistry , stereochemistry , catalysis , materials science , biology , metallurgy , polyurethane , genetics
Carbodiimide, obtained from aza‐Wittig reaction of iminophosphorane with 4‐fluorophenyl isocyanate, reacted with various nucleophiles under mild conditions to give a series of 2‐substituted‐3‐(4‐fluorophenyl)‐benzofuro [3,2‐d] pyrimidin‐4(3H)‐ones in satisfactory yield. Their structures were confirmed using NMR, EI‐Ms, IR, and elementary analysis, and compound 7b was further analyzed by single‐crystal. The preliminary bioassays indicated that these compounds showed moderate fungicidal activities against six kinds of fungi at a concentration of 50 mg/L. J. Heterocyclic Chem., 2010.