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Synthesis, Characterization, and Antimicrobial Evaluation of the Novel Triazolotriazolopyridines and Pyridotriazolotriazines
Author(s) -
ElKazak Azza M.,
Ibrahim Magdy A.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2749
Subject(s) - chemistry , antimicrobial , pyridine , elemental analysis , stereochemistry , combinatorial chemistry , spectral analysis , characterization (materials science) , medicinal chemistry , organic chemistry , nanotechnology , spectroscopy , materials science , physics , quantum mechanics
The starting compound 2‐hydrazinyl‐7‐(4‐methoxyphenyl)‐5‐oxo‐3,5‐dihydro[1,2,4]triazolo[1,5‐ a ]pyridine‐6,8‐dicarbonitrile ( 5 ) was efficiently synthesized from 1,6‐diamino‐4‐(4‐methoxyphenyl)‐2‐oxo‐1,2‐dihydropyridine‐3,5‐dicarbonitrile ( 1 ). A novel series of polynuclear [1,2,4]triazolo[4′,3′:2,3][1,2,4]triazolo[1,5‐ a ]pyridines 6 , 7 , 8 , 9 , 10 and pyrido[1′,2′:2,3][1,2,4]triazolo[5,1‐ c ][1,2,4]triazines 11 , 12 , 13 , 14 , 15 have been synthesized. Structures of the newly synthesized products have been deduced on the basis of elemental analysis and spectral data. The synthesized compounds were screened for their antimicrobial activity .