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Synthesis of Some New Azoloazines with Potent Anti‐inflammatory and Analgesic Activity
Author(s) -
Dawood Dina H.,
Jasass Rabab S.,
Amin Mohamed M.,
Farghaly Thoraya A.,
Abbas Eman M. H.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2746
Subject(s) - chemistry , analgesic , pyrimidine , combinatorial chemistry , pharmacology , analgesic agents , stereochemistry , medicine
Starting from pyrimidine‐2‐thiones, a set of new fused triazoles, thiazoles, and thiazines has been obtained. The mechanistic pathway and structures of all the novel products were ascertained on the foundation of spectral information and elemental analyses. The analgesic and anti‐inflammatory activities of all the prepared compounds were predestined. The outcomes disclosed that all of the examined samples revealed potent activity. Moreover, the relation between the structure and the activity has been researched.