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Synthesis of Certain New Thiazole and 1,3,4‐Thiadiazole Derivatives via the Utility of 3‐Acetylindole
Author(s) -
Abdelhamid Abdou O.,
Gomha Sobhi M.,
Kandeel Saher M.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2740
Subject(s) - chemistry , thiazole , triethylamine , hydrazine (antidepressant) , thiadiazoles , elemental analysis , alkyl , medicinal chemistry , halide , organic chemistry , combinatorial chemistry , chromatography
2‐(2‐(1‐(1 H ‐Indol‐3‐yl)ethylidene)‐hydrazinyl)‐4‐substituted 5‐(aryldiazenyl)thiazoles and 5‐((1‐(1 H ‐indol‐3‐yl)ethylidene)hydrazono)‐2‐substituted‐4‐phenyl‐4,5‐dihydro‐1,3,4‐thiadiazoles were synthesized via reaction of hydrazonoyl halides and 2‐(1‐(1 H ‐indol‐3‐yl)ethylidene)hydrazine‐1‐carbothioamide and alkyl 2‐(1‐(1 H ‐indol‐3‐yl)ethylidene)hydrazine‐1‐carbodithioate in ethanolic triethylamine. Structures of the newly synthesis were elucidated on the basis of elemental analysis, spectral data, and alternative synthetic route whenever possible.