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Synthesis and Biological Activity of Anthranilic Diamide Derivatives Incorporating 1,3,4‐oxadiazole or Nitrogen‐containing Saturated Heterocyclic Moieties
Author(s) -
Zhou WenJuan,
Zhang Li,
Xiao Wei,
Chen HeJu,
Wu WenNeng,
Ouyang GuiPing
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2724
Subject(s) - ralstonia solanacearum , xanthomonas oryzae , chemistry , anthranilic acid , antibacterial activity , oxadiazole , bacteria , xanthomonas , combinatorial chemistry , pyricularia , organic chemistry , biochemistry , botany , genetics , biology , gene
A series of novel anthranilic diamide derivatives incorporating 1,3,4‐oxadiazole or nitrogen‐containing saturated heterocyclic moieties were synthesized, characterized, and evaluated for bacteriostatic activity against three phytopathogenic bacteria Xanthomonas oryzae pv. Oryzae (Xoo), Xanthomonas axonopodis pv. Citri (Xac), Ralstonia solanacearum (R. solanacearum) . The preliminary biological results indicated that most compounds exhibit bacteriostatic activity against three phytopathogenic bacteria. Among these compounds, compounds 6g , 6f , and 6i displayed better antibacterial activity . In the test with concentration of 200 µg/mL, antibacterial activity of compound 6i and 6j was 96%. In particular, the bacteriostatic activity displayed by compound 6h against Xoo is similar to the one displayed by commercial drug bismerthiazol.