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One‐Pot Three‐Component Synthesis of Pyrido[2,3‐ c ]carbazole Derivatives in EtOH under Catalyst‐Free Conditions
Author(s) -
Zhang MeiMei,
Wang Jie,
Wang XiangShan
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2717
Subject(s) - chemistry , catalysis , cyclopentane , carbazole , amine gas treating , component (thermodynamics) , organic chemistry , medicinal chemistry , phthalide , thermodynamics , physics
A three‐component reaction of aromatic aldehydes, 9‐ethyl‐9 H ‐carbazol‐3‐amine, and cyclopentane‐1,3‐dione or tetronic acid was carried out in EtOH at refluxing and gave two series of 2,3,7,12‐tetrahydrocyclopenta[5,6]pyrido[2,3‐ c ]carbazol‐1(4 H )‐one and 3,4,7,12‐tetrahydro‐1 H ‐furo[3′,4′:5,6]pyrido[2,3‐ c ]carbazol‐1‐one derivatives, respectively. This procedure approach to pyrido[2,3‐ c ]carbazoles has the advantages of milder reaction conditions, one‐pot, catalyst free, and high yields.