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Regioselective synthesis of pyrimido[5,4‐c][2,1]benzothiazines by reactions of β‐chloroaldehydes with n‐c‐n binucleophiles
Author(s) -
Popov Kirill,
Volovnenko Tatyana,
Turov Alexander,
Volovenko Yulian
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.271
Subject(s) - regioselectivity , chemistry , pyrimidine , ring (chemistry) , structural isomer , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , catalysis
The method of pyrimidine ring fusion at the [ c ] side of benzothiazines based on the reaction of their chloroaldehyde derivatives with amidines is described. Formation of the structural isomers of reaction products was investigated, and regioselectivity of heterocyclization reactions was shown. A number of novel pyrimidobenzothiazines were synthesized. J. Heterocyclic Chem., 2010.