Premium
Derivational, Structural, and Biological Studies of Some New Pyrazolyl, Isoxazolyl, Pyrimidinyl, Pyridazinyl, and Pyridopyridazinyl from 4‐Substituted Antipyrine
Author(s) -
Fadda Ahmed A.,
Rabie Ramy,
Bondock Samir,
Etman Hassan A.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2707
Subject(s) - chemistry , fusarium oxysporum , isoxazole , bacillus subtilis , bacteria , carbon 13 nmr , pyrazole , antibacterial activity , escherichia coli , quinazoline , proton nmr , pyrimidine , nuclear chemistry , stereochemistry , biochemistry , botany , genetics , gene , biology
(1,5‐Dimethyl‐3‐oxo‐2‐phenyl‐2,3‐dihydro‐1 H ‐pyrazol‐4‐yl)carbono‐hydrazonoyl dicyanide was used as a key intermediate for the synthesis of novel pyrazole, isoxazole, pyrimidine, and pyridazine derivatives. The newly synthesized compounds were characterized by elemental analyses and spectral data (IR, 1 H‐NMR, 13 C‐NMR, and mass spectra). The compounds were tested for their in vitro antibacterial activity against Gram‐positive bacteria as ( Staphylococcus aureus and Bacillus subtilis ) and Gram‐negative bacteria ( Pseudomonas aeruginosa and Escherichia coli ). The investigated compounds were tested against two strains of fungi Botrytis fabae and Fusarium oxysporum using diffusion agar technique. The biological results showed clearly that most of the synthesized compounds revealed mild to moderate activity against the used microorganisms.