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One‐pot Synthesis , Crystal structure, and Bioactivity of N ‐Phenoxyacetyl‐2,4,5‐trisubstituted‐1,3‐oxazolidines
Author(s) -
Fu Ying,
Chen WenGeng,
Hou YuWen,
Wang Bin,
Zhao LiXia,
Ye Fei
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2706
Subject(s) - chemistry , oxazolidine , acylation , ketone , alcohol , carbon 13 nmr , chloride , proton nmr , elemental analysis , acetyl chloride , organic chemistry , medicinal chemistry , stereochemistry , catalysis
N ‐phenoxyacetyl‐1,3‐oxazolidine derivatives were synthesized by the cyclization and acylation with β‐amino alcohol, ketone, and phenoxyacetyl chloride as the starting materials. All compounds were characterized by IR, 1 H NMR, 13 C NMR, ESI‐MS, and elemental analysis. The configuration of 4a was determined by X‐ray crystallography. The preliminary biological tests showed that all products could protect soybean against injury caused by 2,4‐D butylate to some extent.