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Hydrazonoyl Halides Precursors to Synthesis of New Thiazole, Thiadiazole, and Benzothiazepine Derivatives
Author(s) -
ElHag Fatma A. A.,
Gomha Sobhi M.,
Farghaly Thoraya A.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2688
Subject(s) - chemistry , thiazole , halide , thiadiazoles , medicinal chemistry , stereochemistry , organic chemistry
New series of substituted thiazole and thiadiazoles were prepared starting from N ′‐(3,4‐dihydronaphthalen‐1(2 H )‐ylidene)hydrazinecarbothiohydrazide by reacting with different types of hydrazonoyl chlorides. In addition, 7‐(4‐chlorophenyl)‐5,6,6a,7‐tetrahydrobenzo [ b ]naphtha‐[1,2‐ e ][1,4]thiazepine reacted with hydrazonoyl halides to afford a new derivatives of 7‐(4‐chlorophenyl)‐14‐phenyl‐5,6,6a,7‐tetrahydro‐16 H ‐benzo[b]naphtho[1,2‐e][1,2,4]triazolo[4,3‐ d ][1,4]thiazepine. Structures of the newly synthesized compounds were elucidated on the basis of elemental analyses and spectral data.