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Design, Synthesis, and Acaricidal Activities of Novel Pyrazole Acrylonitrile Compounds
Author(s) -
Huang Danling,
Huang Mingzhi,
Liu Aiping,
Liu Xingping,
Liu Weidong,
Chen Xiaoyang,
Xue Hansong,
Sun Jiong,
Yin Dulin,
Wang Xiaoguang
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2682
Subject(s) - acrylonitrile , chemistry , pyrazole , pyrethroid , organic chemistry , combinatorial chemistry , medicinal chemistry , pesticide , agronomy , copolymer , biology , polymer
Using cyenopyrafen as the lead compound, a series of novel pyrazole acrylonitrile compounds were designed and synthesized via the reaction of butylphenylacetonitrile with the corresponding (substituted pyrazol‐5‐yl) methanone of pyrethroid alcohols in the presence of potassium tert‐butoxide. These compounds showed prominent acaricidal activity against Tetranchus urticae . In particular, IIf , IIh , IIo , and IIp displayed excellent activities, which the median lethal concentrations were all lower 0.4 mg/L. In addition, the structure‐activity relationship for the target compounds was discussed.