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Piperidine mediated synthesis of n ‐heterocyclic chalcones and their antibacterial activity
Author(s) -
Venkatesan P.,
Sumathi S.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.268
Subject(s) - chemistry , piperidine , antibacterial activity , antimicrobial , aryl , proton nmr , elemental analysis , condensation , stereochemistry , organic chemistry , medicinal chemistry , combinatorial chemistry , bacteria , genetics , alkyl , physics , biology , thermodynamics
The chalcones 1‐(2′‐hydroxy‐aryl)‐3‐(1‐indol‐3‐yl)‐prop‐2‐en‐1‐one (3) and 1‐(2′‐hydroxy‐aryl)‐3‐(2‐chloroquinolin‐3‐yl)‐prop‐2‐en‐1‐one (6) were synthesised by piperidine mediated condensation of an ethanolic solution of an o ‐hydroxyacetophenone (1) with corresponding heteroaryl‐3‐carboxaldehyde. The structures have been established on the basis of elemental (C, H, N) analysis, UV, IR, 1 H NMR spectral data. The compounds 3 and 6 were screened for antimicrobial activities against a variety of bacterial agents. J. Heterocyclic Chem., 2010.
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