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Efficient Synthesis of 9H‐Pyrrolo[1,2‐ α ]Indoles via Michael Addition–Condensation of 3‐Substituted Indoles with α,β‐Unsaturated Ketimines
Author(s) -
Zhang Minmin,
Liao Lihua,
Yu Shuowen,
Liao Yijun,
Xu Xiaoying,
Yuan Weicheng,
Zhang Xiaomei
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2661
Subject(s) - chemistry , michael reaction , condensation , catalysis , organic chemistry , physics , thermodynamics
By employing copper dibromide as a catalyst, Michael addition–condensation of 3‐substituted indoles with α,β‐unsaturated ketimines was realized. The reactions afforded a large variety of 9H‐pyrrolo[1,2‐ α ]indoles with good yields (up to 99 %). In addition, a plausible reaction mechanism was proposed.