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(Substituted Ylidene)Amino‐2‐Oxo‐Indolylidene Thioureas and Bis(2‐Oxo‐Indolylidene)Urea from (Ylidene)Thiocarbonohydrazides and Isatylidene Malononitrile
Author(s) -
Hassan Alaa A.,
Mohamed Shaaban K.,
AbdelLatif Fathy F.,
Mostafa Sara M.,
AbdelAziz Mohamed,
Mague Joel T.,
Akkurt Mehmet,
Bräse Stefan,
Nieger Martin
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2660
Subject(s) - malononitrile , chemistry , urea , nucleophile , medicinal chemistry , organic chemistry , catalysis
A simple and efficient synthesis of (substituted ylidene)(2‐oxoindolylidene)thiocarbohydrazones and bis(2‐oxoindolylidene)urea was achieved by the reaction of (substituted ylidene)thiocarbonohydrazides with isatylidene malononitrile. Rational for this conversation involving the nucleophilic additions on the dicyanomethylene carbon atom is presented. The structures of the products have been confirmed by using spectral and single‐crystal X‐ray analyses.