Premium
Synthesis and Antimicrobial Activity of Some Novel Quinoline, Chromene, Pyrazole Derivatives Bearing Triazolopyrimidine Moiety
Author(s) -
AbuHashem A. A.,
Gouda M. A.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2645
Subject(s) - chemistry , acrylonitrile , moiety , quinoline , antimicrobial , pyrazole , coumarin , proton nmr , elemental analysis , combinatorial chemistry , organic chemistry , copolymer , polymer
7‐Amino‐3‐phenyl‐[1,2,4]triazolo [4,3‐a] pyrimidin‐5(1 H )‐one ( 5 ) was utilized as key intermediate for the synthesis of some new, quinolines 9 , 10 , 11 , 12 , 13 , 14 and 18 , 19 , 20 , acrylonitrile 25 and 28 , coumarin 26 , and pyrazoles 31 , 32 , 33 , 34 incorporating triazolopyrimidines. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, 1 H NMR, and mass spectral data. Representative compounds of the synthesized products were tested and evaluated as antimicrobial. Compounds 25 , 28 , 31 , 32 , 33 , and 34 are the most promising.