Synthesis and  Antimicrobial Activity  of Some Novel Quinoline, Chromene, Pyrazole Derivatives Bearing Triazolopyrimidine Moiety | Zendy

AbuHashem A. A. | Zendy; Gouda M. A. | Zendy

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Synthesis and Antimicrobial Activity of Some Novel Quinoline, Chromene, Pyrazole Derivatives Bearing Triazolopyrimidine Moiety

Author(s) -

AbuHashem A. A.,

Gouda M. A.

Publication year - 2017

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2645

Subject(s) - chemistry , acrylonitrile , moiety , quinoline , antimicrobial , pyrazole , coumarin , proton nmr , elemental analysis , combinatorial chemistry , organic chemistry , copolymer , polymer

7‐Amino‐3‐phenyl‐[1,2,4]triazolo [4,3‐a] pyrimidin‐5(1 H )‐one ( 5 ) was utilized as key intermediate for the synthesis of some new, quinolines 9 , 10 , 11 , 12 , 13 , 14 and 18 , 19 , 20 , acrylonitrile 25 and 28 , coumarin 26 , and pyrazoles 31 , 32 , 33 , 34 incorporating triazolopyrimidines. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, 1 H NMR, and mass spectral data. Representative compounds of the synthesized products were tested and evaluated as antimicrobial. Compounds 25 , 28 , 31 , 32 , 33 , and 34 are the most promising.

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