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Synthesis and antifungal activity of novel 2‐benzimidazolylimino‐5‐arylidene‐4‐thiazolidinones
Author(s) -
Mobinikhaledi Akbar,
Foroughifar Naser,
Kalhor Mehdi,
Mirabolfathy Mansoureh
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.264
Subject(s) - chemistry , carbendazim , antifungal , rhizoctonia solani , benzimidazole , fungicide , botrytis , gibberella zeae , phytophthora nicotianae , botrytis cinerea , stereochemistry , aldehyde , fusarium , organic chemistry , phytophthora , botany , microbiology and biotechnology , biology , catalysis
A series of 5‐arylidene derivatives 3a‐k , as potential antifungal agents , were synthesized in good to high yields by the reaction of 2‐benzimidazolylimino‐4‐thiazolidinone and corresponding aromatic aldehyde in a buffered medium. These compounds were evaluated for their antifungal activities against four agricultural fungi, Botrytis elliptica , Fusarium graminearum, Phytophthora nicotianae , and Rhizoctonia solani . Thereby, it was found that the compound 1 exhibits an antifungal effect against P. nicotianae and B. elliptica , comparable with carbendazim as a standard antifungal. Our results may provide some guidance for development of some novel benzimidazole‐based antifungal lead structures. J. Heterocyclic Chem., 2010.