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Synthesis, Characterization, Antibacterial, and Antifungal Activity of Novel 2‐(2‐hydroxy‐5‐((aryl)‐diazenyl)phenyl)‐3‐(4‐hydroxyphenyl)‐thiazolidin‐4‐one
Author(s) -
Chopde Himani N.,
Pandhurnekar Chandrashekhar P.,
Meshram Jyotsna S.,
Pagadala Ramakanth
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2620
Subject(s) - thioglycolic acid , chemistry , aryl , benzaldehyde , phenol , antifungal , antibacterial activity , mass spectrum , proton nmr , organic chemistry , elemental analysis , medicinal chemistry , bacteria , catalysis , microbiology and biotechnology , alkyl , ion , genetics , biology
A series of novel thiazolidinones, that is, 2‐(2‐hydroxy‐5‐((aryl)‐diazenyl)phenyl)‐3‐(4‐hydroxyphenyl)‐thiazolidin‐4‐one, have been synthesized by reaction of various Schiff bases 2‐(4‐hydroxyphenylimino)methyl)‐4‐(aryl)diazenyl)phenol with ethanolic thioglycolic acid. Schiff bases were obtained by the reactions of 4‐amino phenol with 2‐hydroxy‐5‐((aryl)diazenyl)benzaldehyde. The structures of the newly synthesized compounds were confirmed by IR, 1 H NMR, mass spectra, and C, H, N elemental analysis. The thiazolidinone derivatives were evaluated for their antibacterial and antifungal activity.