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Synthesis and crystal structure characterization of 3,5‐bis(2‐quinolyl)‐1,2,4‐triazole
Author(s) -
Cheng HuiMin,
Zhu DunRu,
Lu Wei,
Xu RenHui,
Shen Xuan
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.262
Subject(s) - chemistry , yield (engineering) , 1,2,4 triazole , crystal structure , characterization (materials science) , triazole , stereochemistry , crystallography , combinatorial chemistry , medicinal chemistry , organic chemistry , nanotechnology , metallurgy , materials science
The first quinolyl substituted 1,2,4‐triazole, 3,5‐bis(2‐quinolyl)‐1,2,4‐triazole ( 4 ), was synthesized from 2‐cyanoquinoline ( 1 ) through an intermediate 2‐quinolylhydrazidine ( 2 ) with 60.4% yield in a simple way. In the synthetic process of 4 , another new intermediate, 1,4‐diamino‐1,4‐bis(2‐quinolyl)‐2,3‐diaza‐1,3‐butadiene ( 3 ) was obtained in a yield of 81.5%. Additionally, the absolute configurations of both 3 and 4 were determined by X‐ray crystallography. J. Heterocyclic Chem., 2010.
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