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One‐pot Synthesis of Benzo[4,5]imidazo[1,2‐ a ]pyridine Derivatives in Aqueous Conditions
Author(s) -
Vodolazhenko Maria A.,
Mykhailenko Anastasiia E.,
Gorobets Nikolay Yu.,
Desenko Sergey M.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2617
Subject(s) - chemistry , pyridine , acetonitrile , solvent , dimethylformamide , aqueous solution , medicinal chemistry , organic chemistry , combinatorial chemistry
One‐pot reaction of cyclic 1,3‐diketones, dimethylformamide dimethylacetal (DMFDMA) and 2‐(1 H ‐benzo[ d ]imidaz‐2‐yl)acetonitrile was found to be a highly selective process leading to 4‐oxo‐1,2,3,4‐tetrahydrobenzo[4,5]imidazo[1,2‐ a ]quinolin‐6‐yl cyanides. Optimized reaction conditions using water as solvent at room temperature or under microwave heating allowed high yields of the target products required no additional purification.