z-logo
Premium
Design and Synthesis of Novel Quinoline Tethered Tricyclic 1,5‐Benzothiazepine Derivatives via 1,3‐Dipolar Cycloaddition Reaction
Author(s) -
Yang Peng,
Lin Hui,
Fei Tinghong,
Liu Fangming
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2614
Subject(s) - chemistry , quinoline , cycloaddition , adduct , 1,3 dipolar cycloaddition , tricyclic , ring (chemistry) , crystal structure , stereochemistry , single crystal , proton nmr , medicinal chemistry , crystallography , organic chemistry , catalysis
A series of novel substituted‐[1,2,4]oxadiazolo[5,4‐d][1,5]benzothiazepine derivatives contain quinoline ring 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i , 5j , 5k , 5l were synthesized by the reaction of benzothiazepines 4a , 4b , 4c and substituted‐benzohydroximinoyl chlorides through the 1,3‐dipolar cycloaddition reaction in the presence of Et 3 N at room temperature. The structures of the obtained adducts were elucidated by MS, IR, 1 H NMR, and elemental analyses. In addition, the structures of 5e were further confirmed by X‐ray single crystal diffraction study.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here