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Efficient Synthesis of Pyrrolo [2,3‐d] Pyrimidines Containing 1,4‐Disubstituted‐1,2,3‐Triazole Derivatives
Author(s) -
Ruddarraju Radhakrishnamraju,
Murugulla Adharvana Chari,
Donthabakthuni Shobha,
Kotla Ravindar,
Deshmukh Sandeep,
Maroju Ravichandar,
Palle Sadhanandam
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2611
Subject(s) - chemistry , alcohol , derivative (finance) , 1,2,4 triazole , proton nmr , combinatorial chemistry , carbon 13 nmr , triazole , medicinal chemistry , stereochemistry , organic chemistry , financial economics , economics
Here, we demonstrate a simple but highly efficient method for the synthesis of multifunctionalized pyrrolo[2,3‐d]pyrimidines containing 1,4‐disubstituted 1,2,3‐triazole derivative coupled with various amines ( 10a , 10b , 10c , 10d , 10e , 10f , 10g ) and alcohol ( 10h ) to obtain final compounds ( 11a , 11b , 11c , 11d , 11e , 11f , 11g , 11h ) with reasonable to excellent yields (25% to 94%). The newly synthesized compounds were characterized by IR, 1 HNMR, 13 CNMR, and mass spectroscopy analysis.
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