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One‐Pot Synthesis of Regioselective Polysubstituted Indolizines via Three‐Component Reactions of Dialkyl Acetylendicarboxylates, Dialkylchloro Malonates, and Pyridines
Author(s) -
Piltan Mohammad,
Kalantari Shahin
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2604
Subject(s) - indolizine , chemistry , regioselectivity , component (thermodynamics) , organic chemistry , combinatorial chemistry , catalysis , physics , thermodynamics
An efficient and novel approach to the synthesis of 1,2,3‐trisubstituted indolizines has been achieved via the reaction of pyridines, dialkyl acetylendicarboxylates, and dialkyl chloromalonates. The corresponding 1,2,3‐trisubstituted indolizines may be useful building blocks for the construction of complex indolizine derivatives.