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Triphenylphosphine (PPh 3 ) Catalyzed Erlenmeyer Reaction for Azlactones under Solvent‐free Conditions
Author(s) -
Punna Rao Alapati Mohan Lakshmi,
Sridhar Rao Abburi,
Saratchandra Babu Mukkamala,
Krishnaji Rao M.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2600
Subject(s) - chemistry , hippuric acid , triphenylphosphine , acetic acid , organic chemistry , catalysis , solvent , biochemistry , urine
This study presents triphenylphosphine catalyzed process for the synthesis of azlactones and their derivatives using hippuric and substituted aromatic aldehydes. The methodology also found to be effective for the synthesis of azlactones from 5‐(2,6‐dichlorophenyl)‐3‐methyl‐1,2‐oxazol‐4‐yl carbonyl amino acetic acid and offers several advantages such as solvent‐free conditions, excellent yields, simple procedure, mild conditions, and reduced environmental consequences.