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Iodine/Water Mediated Parallel Synthesis of Bioactive Diversely Substituted Pyrazolo‐Pyrido‐Pyrimidines and Its Spiro Analogues: An Enviro‐Economic Approach
Author(s) -
Sagir Hozeyfa,
Rai Pragati,
Tiwari Shailendra,
Siddiqui I. R.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2596
Subject(s) - chemistry , isatin , iodine , aldehyde , combinatorial chemistry , ethyl acetoacetate , hydrazine (antidepressant) , organic chemistry , recrystallization (geology) , catalysis , chromatography , paleontology , biology
A convenient, green, and efficient protocol for the synthesis of diversely substituted pyrazolo‐pyrido‐pyrimidines has been described by a simple one‐pot four‐component reaction of hydrazine, ethyl acetoacetate, 6‐amino‐1‐methyluracil, and isatin or aldehyde catalyzed by iodine in water. Environmental friendliness, operational simplicity, low cost, high yields, and applicability to a wide range of readily available starting materials are the key features of this methodology. Most importantly, workup of this very clean strategy involves only filtration and simple washing step without any traditional chromatography and recrystallization purifications, thus reducing time, waste, and cost.