Synthesis and Biological Evaluation of Some Novel Isoxazole Derivatives | Zendy

Hamama W. S. | Zendy; Ibrahim M. E. | Zendy; Zoorob H. H. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis and Biological Evaluation of Some Novel Isoxazole Derivatives

Author(s) -

Hamama W. S.,

Ibrahim M. E.,

Zoorob H. H.

Publication year - 2017

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2589

Subject(s) - isoxazole , chemistry , alkylation , pyridine , mannich reaction , derivative (finance) , hydrochloride , imidazole , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , financial economics , economics

The reaction of 5‐amino‐3‐methylisoxazole ( 1 ) with formalin and secondary amines gave the corresponding Mannich bases 3 , 4 , 5 , 6 . Alkylation of isoxazole derivative 1 with Mannich bases hydrochloride gave unsubstituted isoxazolo[5,4‐ b ]pyridine derivatives 8a , 8b via alkylation at position 4. Moreover, coupling reaction of 1 with different diazonium salts gave the corresponding mono and bisazo dyes of isoxazole derivative. The newly synthesized compounds were screened for their antitumor activity compared with 5‐fluorouracil as a well‐known cytotoxic agent using Ehrlich ascites carcinoma cells. Interestingly, the obtained results showed clearly that compounds 3 , 15 , 8b , 4 , 8a , and 5 exhibited high antitumor activity than 5‐fluorouracil.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research