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Synthesis of Some New 1,3,4,5‐tetrasubstituted‐1 H ‐imidazole‐2(3 H )‐thiones Via a Facile One‐Pot Three‐Component Reaction in the Presence of Solvent and Heteropolyacids
Author(s) -
Shaker Mohammad,
Davoodnia Abolghasem,
Vahedi Hooshang,
Lari Jalil,
Roshani Mina,
Mallaeke Hassan
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2585
Subject(s) - chemistry , imidazole , benzoin , acetic acid , component (thermodynamics) , one pot synthesis , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , physics , thermodynamics
A simple and efficient synthesis of 1,3,4,5‐trisubstituted‐1 H ‐imidazole‐2(3 H )‐thiones via a one‐pot three‐component reaction of benzoin with isothiocyanates and aromatic amines in the presence of glacial acetic acid and heteropolyacid is described. All synthesized compounds were characterized on the basis of their spectral and microanalytical data.