Premium
3‐(3,5‐Dimethyl‐1 H ‐Pyrazol‐1‐yl)‐3‐Oxopropanenitrile as Precursor for Some New Mono‐Heterocyclic and Bis‐Heterocyclic Compounds
Author(s) -
Metwally Nadia H.,
Abdelrazek Fathy M.,
Eldaly Salwa M.,
Metz Peter
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2578
Subject(s) - chemistry , acetanilide , phenacyl bromide , phenyl isothiocyanate , isothiocyanate , aryl , azo coupling , medicinal chemistry , condensation , derivative (finance) , bromide , organic chemistry , combinatorial chemistry , alkyl , physics , financial economics , economics , thermodynamics
3‐(3,5‐Dimethyl‐1 H ‐pyrazol‐1‐yl)‐3‐oxopropanenitrile 1 was used as a cyanoacetylating agent for synthesis of the acetanilide derivative 3 . Compound 3 was utilized as a key intermediate for the synthesis of some new mono‐chromene and di‐chromene derivatives 9 and 13 , the dihydrazo derivatives 15 , and the dithiazole derivatives 18 via the condensation with o ‐hydroxybenzaldehyde derivatives, the coupling with aryl diazonium salts, or the reaction with phenyl isothiocyanate in presence of KOH followed by phenacyl bromide derivatives respectively.