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Synthesis and Antioxidant Evaluation of Some Novel Thiophene, Pyrazole, Chromene, Pyrazolotriazine Derivatives Bearing Sulfonamide Moiety
Author(s) -
Gouda Moustafa A.
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2576
Subject(s) - chemistry , cyanoacetamide , thiophene , sulfonamide , pyrazole , moiety , antioxidant , pyridine , combinatorial chemistry , thiazole , organic chemistry
As a part of ongoing studies in developing new potent antioxidant agents, N ‐[4‐(aminosulfonyl)phenyl]‐2‐cyanoacetamide ( 3 ) was utilized as key intermediate for the synthesis of some new thiophene, chromene, and pyrazolotriazine pyridine derivatives . The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, 1 H‐NMR, and mass spectral data. Representative compounds of the synthesized products were tested and evaluated as antioxidant. Compounds 7 and 30 are promising compounds.