Premium
Synthesis of Novel Quinoline‐substituted 1,4‐dihydropyridine Derivatives via Hantzsch Reaction in Aqueous Medium: Potential Bioactive Compounds
Author(s) -
Shiri Morteza,
NejatinezhadArani Atefeh,
Faghihi Zeinab
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2553
Subject(s) - chemistry , quinoline , ammonium acetate , aqueous medium , aqueous solution , alkyl , catalysis , solvent , combinatorial chemistry , organic chemistry , dihydropyridine , calcium , high performance liquid chromatography
The synthesis of a novel series of substituted 1,4‐dihydropyridines was achieved in aqueous media by base‐catalyzed three‐component Hantzsch reaction of 2‐chloroquinoline‐3‐carbaldehydes, ammonium acetate, and alkyl acteoacetate in good to high yields. Important advantages of this method are easy access to a library of novel quinoline and quinolone derivatives, green reaction conditions with water as solvent, and ease of purification.