Efficient Preparation of Alkaloids Polycarpine and Polycarpaurines A and C | Zendy

Guo Pengbin | Zendy; Yan Shuang | Zendy; Hu Zeliang | Zendy; Zhuang Weihui | Zendy; Xiong Yan | Zendy; Zhang Lanya | Zendy; Wang Ziwen | Zendy; Wang Qingmin | Zendy

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Efficient Preparation of Alkaloids Polycarpine and Polycarpaurines A and C

Author(s) -

Guo Pengbin,

Yan Shuang,

Hu Zeliang,

Zhuang Weihui,

Xiong Yan,

Zhang Lanya,

Wang Ziwen,

Wang Qingmin

Publication year - 2017

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2549

Subject(s) - chemistry , yield (engineering) , carbon 13 nmr , organic chemistry , metallurgy , materials science

An efficient method for the preparation of alkaloids polycarpine and polycarpaurines A and C via microwave‐assisted three‐step one‐pot reaction as the key step has been developed. This is the first report about the synthesis of polycarpaurines A and C. Starting from commercially available p ‐methoxybenzaldehyde, polycarpine and polycarpaurine A were obtained over seven steps with 40 and 24 % overall yield, respectively. Polycarpine could convert to polycarpaurine C in 72% yield in the presence of NaHSO 3 . The structure of polycarpine and polycarpaurines A and C was confirmed by 1 H NMR, 13 C NMR, and HRMS.

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