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Synthesis and Regioselectivity in the Alkylation of 1,3,4‐Oxadiazolethiones with Dihaloalkanes and Epichlorohydrin
Author(s) -
El Ashry El Sayed H.,
Boraei Ahmed T. A.,
Duerkop Axel
Publication year - 2017
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2545
Subject(s) - regioselectivity , chemistry , alkylation , epichlorohydrin , thiirane , ring (chemistry) , alkyl , halide , epoxide , alicyclic compound , organic chemistry , catalysis
The regioselectivity in the alkylation of 1,3,4‐oxadiazolethiones with dihaloalkanes was found that it depends mainly on the length of the alkyl chain connecting the two halides; moreover, the formation of thiirane ring instead of epoxide ring during the alkylation with epichlorohydrin was surprising.