Synthesis of Novel Fused Heterocycles Based on 6‐Amino‐4‐phenyl‐2‐thioxo‐1,2‐dihydropyridine‐3,5‐dicarbonitrile | Zendy

AbdelGhany H. | Zendy; ElSayed A. M. | Zendy; Amer A. A. | Zendy; Ahmed A. M. | Zendy

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Synthesis of Novel Fused Heterocycles Based on 6‐Amino‐4‐phenyl‐2‐thioxo‐1,2‐dihydropyridine‐3,5‐dicarbonitrile

Author(s) -

AbdelGhany H.,

ElSayed A. M.,

Amer A. A.,

Ahmed A. M.

Publication year - 2016

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2522

Subject(s) - chemistry , formic acid , chloroacetyl chloride , pyridine , formamide , acrylonitrile , acetic anhydride , dihydropyridine , catalysis , medicinal chemistry , pyrimidine , organic chemistry , combinatorial chemistry , chloride , stereochemistry , copolymer , calcium , polymer

Under phase transfer catalysis conditions, 6‐amino‐4‐phenyl‐2‐thioxo‐1,2‐dihydropyridine‐3,5‐dicarbonitrile ( 1 ) was allowed to react with halo compounds, acrylonitrile, chloroacetyl chloride, ethyl cyanoacetate, formamide, triethylorthoformate, or formic acid to give new derivatives of fused pyridines 2–22, respectively. Acetylation of compound 1 using acetic anhydride afforded product 23 , which in turn underwent intramolecular cyclization in pyridine to give the corresponding pyrido[2,3‐ d ]pyrimidine 24 .

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