Premium
N ‐substituted isoquinoline derivatives as potential AChE inhibitors
Author(s) -
Gitto Rosaria,
De Luca Laura,
Ferro Stefania,
De Grazia Sara,
Di Giorgio Rosa Maria,
Festa Filomena,
De Luca Grazia
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.252
Subject(s) - chemistry , isoquinoline , acetylcholinesterase , aché , donepezil , inhibitory postsynaptic potential , combinatorial chemistry , stereochemistry , organic chemistry , enzyme , medicine , dementia , disease , pathology , neuroscience , biology
AbstractN ‐substituted donepezil‐related isoquinolines have been prepared as potential acetylcholinesterase inhibitors (AChEIs). Microwave assisted procedures and solution‐phase parallel synthesis were chosen to optimize the synthetic approach and improve the yields. All synthesized compounds were tested for their AChE inhibitory activity by colorimetric Ellman method and some of them ( 10 , 13 , and 28 ) displayed low inhibitory effects at μ M concentrations. J. Heterocyclic Chem., (2010).