A Convenient and Facile Hantzsch Synthesis of Aryl Imidazo[1,2‐ b ]Isoxazolyl‐ N ‐aryl Thiazol Amines

The Hantzsch synthesis of novel aryl imidazo[1,2‐ b ]isoxazolyl‐ N ‐aryl thiazol amines 5 analogues were described. Reaction of 3‐aminoisoxazole 1 with substituted phenacyl bromides 2 in dry ethanol afforded the corresponding 6‐methyl‐3‐arylimidazo[1,2‐ b ]isoxazoles 3 in good yields. Compounds 3 on reaction with chloroacetyl chloride in 1,4‐dioxane furnished the corresponding 2‐chloro‐1‐(6‐methyl‐3‐arylimidazo[1,2‐ b ]isoxazol‐2‐yl)ethanones 4 . Compounds 4 on heating with N ‐aryl thioureas in an oil bath underwent cyclization to afford the title compounds viz ., imidazo[1,2‐ b ]isoxazolyl‐ N ‐aryl thiazol amines 5 in moderate to good yields by Hantzsch synthesis.