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Nickel‐catalyzed Kumada Cross‐coupling Reaction for the Synthesis of 2,4‐Diarylquinazolines
Author(s) -
Ye Xinglin,
Yuan Zhihan,
Zhou Yirong,
Yang Qin,
Xie Yepeng,
Deng Zhihong,
Peng Yiyuan
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2513
Subject(s) - chemistry , aryl , catalysis , reagent , nickel , coupling reaction , combinatorial chemistry , quinazoline , organic chemistry , alkyl
A series of 2,4‐diarylquinazolines have been successfully synthesized via the Ni‐catalyzed cross‐coupling reaction of quinazoline‐4‐tosylates and aryl Grignard reagents, which provided alternative straightforward approaches for the introduction of aryl groups to quinazolines at C‐4 position.