Premium
A Facile Three‐Component One‐Pot Synthesis of Some Novel Tricyclic Hetero‐Ring Systems
Author(s) -
Gomha Sobhi M.,
Abdelrazek Fathy M.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2503
Subject(s) - chemistry , malononitrile , tricyclic , methylene , pyrimidine , ring (chemistry) , component (thermodynamics) , combinatorial chemistry , proton nmr , organic chemistry , stereochemistry , medicinal chemistry , catalysis , physics , thermodynamics
A novel, facile, one‐pot, multicomponent reaction for the synthesis of a series of pyrano[2,3‐ d ][1,2,4]triazolo[4,3‐ a ]pyrimidine and pyrano[2′,3′:4,5]pyrimido[2,1‐b][1,3,5]thiadiazine derivatives has been developed from reaction of 2,4‐dichlorobezaldehyde, malononitrile, and the appropriate active methylene compounds in refluxing dioxane in the presence of chitosan. A plausible mechanism has been proposed for this reaction, and the structure of the newly synthesized compounds was all established on the basis of spectral data (mass, IR, and 1 H‐NMR) and elemental analyses.